Center for Integrative Organ Systems (cenIOS)

The field of regenerative biology is at an important crossroads, and a focus on multi-organ system studies will take center stage in biomedical research, providing the underpinning for translating regenerative medicine discoveries in therapies in the clinic.  Many model systems (e.g., organoids/zebrafish/mouse) can be utilized in these studies and will allow the investigators to understand similarities and difference of how organs respond in many models of injury. In addition, since there are induced pluripotent stem cell (iPSC) models for virtually every organ in the human body, this will allow a “whole system” field to emerge. iPSCs derived from disease subjects allows for interrogation of many human diseases and for unprecedented opportunities to conduct systematic drug screens that can be tailored to individual patients and unique populations.  Studying multiple organ systems with a focus on the same fundamental questions will be the strength of the Center for Integrative Organ Systems (cenIOS), and such a collaborative effort will play a central role in the coming decade of personalized translational medicine.