Congratulations to Dr. Everett Pesci of East Carolina University and co-investigator Dr. Neil Hukriede on their recently funded R01 proposal, Studies on the Pseudomonas Aeruginosa Cell-to-Cell Signal PQS." The goal of the proposed research is to identify small molecules as lead compounds for treatment of Pseudomonas aeruginosa infection.
Congratulations to Dr. Gerard Apodaca and co-investigator Dr. Neil Hukriede on their recently funded R01 proposal, "Role of Uroplakins in Urinary Tract Development and CAKUT." This project proposes that UPK3a plays a critical role in epithelial polarization and morphogenesis, key steps in epithelial differentiation and organogenesis.
Congratulations to Dr. Neil Hukriede and co-investigator Dr. Mark deCaesteckor of Vanderbilt University on the recently funded R01 Supplement, "Regulation of Renal Progenitor Cells in Regenerating Kidneys", recently funded for one year. The purpose of this research is to determine the molecular mechanism by which small molecules act to enhance renal regeneration with the ultimate goal of developing new therapies to treat AKI.
Dr. Dennis Kostka, Assistant Professor in the Department of Developmental Biology, has been awarded a 2-year 2014 March of Dimes Basil O'Connor Research Award. The goal of this grant entitled "Genome-wide Transcriptional Regulation During Embryonic Left-Right Patterning" is to employ computational techniques to identify and characterize gene regulatory enhancer sequences. Dr. Kostka joined the department as an Assistant Professor in 2012 and his research focuses on computational analysis of large-scale genomics data sets.
Congratulations to Dr. Jackie Ho and co-investigator Dr. Dennis Kostka on their recently funded R01 proposal, "The role of miR-17~92 in nephron progenitors." This project will investigate the mechanisms by which miR-17~92 regulates kidney development.
Congratulations to Dr. Cecilia Lo, Dr. Chakra Chennubhotla and Dr. Michael Tsang. Their R01 proposal, "Assaying Heterotaxy Patient Genes in Cilia Motility and Left-Right Patterning," was recently funded for four years. This grant is based on the theory that motile cilia function is required both for airway mucus clearance and embryonic left-right patterning. They will develop functional assays and software to assess cilia candidate genes containing rare coding variants identified in heterotaxy patients for their role in airway cilia motility and left-right patterning of organ asymmetries.
Congratulations to Dr. Donghun Shin on his recently funded R01 proposal, "Elucidating the Mechanisms by which Bmp Signaling Regulates biliary-driven Liver Regeneration." The overall goal of this research is to elucidate the mechanisms by which Bmp signaling regulates this process, which will provide novel insights into how to augment innate liver regeneration in patients as therapeutics.
Congratulations to Dr. Neil Hukriede on the recently funded for 4 years NIH R01 Supplement, "Regulation of Renal Progenitor Cells in Regenerating Kidneys." The purpose of this research is to determine the molecular mechanism by which small molecules act to enhance renal regeneration with the ultimate goal of developing new therapies to treat AKI.
Congratulations to Drs. Alexander Deiter and Michael Tsang on their recently funded Kaufman Foundation proposal, "Expanding the Genetic Code of Zebrafish." They propose to expand the genetic code of a vertebrate animal in order to develop new methodologies that will allow for the spatial and temporal control of protein function through the incorporation of light-activated amino acids in a living organism.
Congratulations to Drs. Claudette St. Croix, Bruchez and Waggoner and co-investigator Dr. Michael Tsang on their recently funded NIH proposal (through Carnegie Mellon University) entitled, "Tandem Chemical Sensors for Endothelial Cell Biology." The overall goal of this application is to identify key regulatory events and effectors responsible for Zn-mediated modulation of endothelial contractile function.
Congratulations to Dr. Lei Yang on his 2014 NIH Director’s New Innovator Award intended to support - per the NIH - "exceptionally creative investigators who propose bold research ideas of unusually broad impact". In the new $2.3 million, five-year project, Dr. Yang and his team will test whether human iPS cell-derived heart progenitor cells could be used to repopulate whole acellular human heart scaffolds for rebuilding whole bioartificial human hearts. In addition, they will examine the effects of human heart ECMs on CM differentiation and maturation from reseeded human heart progenitor cells.
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