Seung-Hoon Lee, Ph.D.

  • Postdoctoral Associate

Seung-Hoon’s research focuses on liver regeneration.

Education & Training

  • Ph.D. from Yonsei University, Seoul, Korea, 2018
  • M.S. from Yonsei University, Seoul, Korea
  • B.S. from Chungang University, Seoul, Korea, 2007

Representative Publications

1. So J, Kim M, Lee SH, Ko S, Lee DA, Park H, Azuma M, Parsons MJ, Prober D, Shin D (2020), Attenuating the EGFR-ERK-SOX9 axis promotes liver progenitor cell-mediated liver regeneration in zebrafish. Hepatology, doi: 10.1002/hep.31437

2. Seung-Hoon Lee, Jae-Su Moon, Bo-Yeong Park, Geon-Woo Kim, Wooseong Lee, Hee Cho, SangKyu Kim and Jong-Won Oh. (2018) HA1077 displays synergistic activity with daclatasvir against hepatitis C virus and suppresses the emergence of NS5A resistance-associated substitutions in mice. Sci. Rep. 8(1):12469.

3. Jae-Su Moon, Seung-Hoon Lee, Song-Hee Han, Eun-Jung Kim, Hee Cho, Wooseong Lee, Mi-Kyung Kim, Tae-Eun Kim, Hyun-Ji Park, Jin-Kyu Rhee, Seong-Jun Kim, Seung-Woo Cho, Seung Hyun Han, Jong-Won Oh. (2016) Inhibition of hepatitis C virus in mouse models by lipidoid nanoparticle-mediated systemic delivery of siRNA against PRK2. Nanomedicine: Nanotechnology, Biology and Medicine 12:1489-1498. Co-first.

4. Jae-Su Moon, Seung-Hoon Lee, Eun-Jung Kim, Hee Cho, Wooseong Lee, Geon-Woo Kim, Hyun-Ji Park, Seung-Woo Cho, Choongho Lee, Jong-Won Oh. (2016) Inhibition of Hepatitis C Virus in Mice by a Small Interfering RNA Targeting a Highly Conserved Sequence in Viral IRES Pseudoknot. PLoS One. 11;014670. Co-first.

5. Wooseong Lee, Seung-Hoon Lee, Minwoo Kim, Jae-Su Moon, Geon-Woo Kim, Hae-Gwang Jung, In Hwang Kim, Ji Eun Oh, Hi Eun Jung, Heung Kyu Lee, Keun Bon Ku, Dae-Gyun Ahn, Seong-Jun Kim, Kun-Soo Kim & Jong-Won Oh. (2018) Vibrio vulnificus quorum-sensing molecule cyclo (Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat. Commun. 9(1):1606, DOI: 10.1038/s41467-018-04075-1.

6. Wooseong Lee, Minwoo Kim, Seung-Hoon Lee, Hae-Gwang Jung and Jong-Won Oh. (2018) Prophylactic efficacy of orally administered Bacillus poly-γ-glutamic acid, a non-LPS TLR4 ligand, against norovirus infection in mice. Sci. Rep. 8(1):8667.

7. Song-Hee Han, Seong-Jun Kim, Eun-Jung Kim, Tae-Eun Kim, Jae-Su Moon, Geon-Woo Kim, Seung-Hoon Lee, Kun Cho, Jong Shin Yoo, Woo Sung Son, Jin-Kyu Rhee, Seung Hyun Han and Jong-Won Oh. (2014) Phosphorylation of hepatitis C virus RNA polymerase Ser29 and Ser42 by PRK2 regulates viral RNA replication. J Virol. 88: 11240-11252.

8. Mi-Gyeong Kim, Jae-Su Moon, Eun-Jung Kim, Seung-Hoon Lee, Jong-Won Oh. (2012) Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis C virus replication through inhibition of PRK2-mediated viral RNA polymerase phosphorylation. Biochem. Biophys. Res. Commun. 421: 112-118.

9. Ji-min Sun, Seong-jun Kim, Geon-woo Kim, Jin-Kyu Rhee, Nam doo Kim, Jungae Jeun, Seung-Hoon Lee, Seung hyun Han, Chul soo Shin, Jong-won Oh. (2012) Inhibition of hepatitis C virus replication by Monascus pigment derivatives that interfere with viral RNA polymerase activity and the mevalonate biosynthesis pathway. J. Antimicrob. Chemother., 67;49-48.

Research Interests

1. To establish zebrafish models for hepatocyte reprogramming to biliary epithelial cells

2. To elucidate the molecular mechanisms of hepatocyte reprogramming

3. The role of epigenetic factors in hepatocyte reprogramming