Hisato Yagi, Ph.D.

  • Research Instructor
  • The genetic etiology of mouse models with hypoplastic left heart syndrome and its underlying mechanism.
  • Transcriptional and epigenetic control of mammalian cardiovascular development and function.
  • Transcriptional and epigenetic control of mammalian left-right patterning.

Representative Publications

  1. An unconventional myosin, myosin 1d regulates Kupffer’s vesicle morphogenesis and laterality. Saydmohammed M, Yagi H, Calder­­­­­­on M, Clark MJ, Feinstein T, Sun M, Stolz DB, Watkins SC, Amack JD, Lo CW, Tsang M. Nature Communication 2018
  2. The Genetic Landscape of Hypoplastic Left Heart Syndrome. Yagi H, Liu X, Gabriel GC, Wu Y, Peterson K, Murray SA, Aronow BJ, Martin LJ, Benson DW, Lo CW. Pediatr Cardiol 2018 Aug;39(6):1069-1081
  3. The complex genetics of hypoplastic left heart syndrome. Liu X, Yagi H, Saeed S, Bais AS, Gabriel GC, Chen Z, Peterson KA, Li Y, Schwartz MC, Reynolds WT1, Saydmohammed M, Gibbs B, Wu Y, Devine W, Chatterjee B, Klena NT, Kostka D, de Mesy Bentley KL, Ganapathiraju MK, Dexheimer P, Leatherbury L, Khalifa O, Bhagat A, Zahid M, Pu W, Watkins S, Grossfeld P, Murray S, Porter Jr GA, Tsang M, Martin LJ, Benson DW, Aronow BJ, Lo CW. Nat Genet. 2017 Jul;49(7):1152-1159
  4. DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia. Li Y*, Yagi H*, Onuoha EO, Damerla RR, Francis R, Furutani Y, Tariq M, King SM, Hendricks G, Cui C, Saydmohammed M, Lee DM, Zahid M, Sami I, Leatherbury L, Pazour GJ, Ware SM, Nakanishi T, Goldmuntz E, Tsang M, Lo CW (*equally contributed). PLoS Genet. 2016 Feb 26;12(2):e1005821.
  5. Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects. Gibbs BC, Damerla RR, Vladar EK, Chatterjee B, Wan Y, Liu X, Cui C, Gabriel GC, Zahid M, Yagi H, Szabo-Rogers HL, Suyama KL, Axelrod JD, Lo CW. Biol Open. 2016 Feb 16;5(3):323-35.
  6. MMP21 is mutated in human heterotaxy and is required for normal left-right asymmetry in vertebrates. Guimier A, Gabriel GC, Bajolle F, Tsang M, Liu H, Noll A, Schwartz M, El Malti R, Smith LD, Klena NT, Jimenez G, Miller NA, Oufadem M, Moreau de Bellaing A, Yagi H, Saunders CJ, Baker CN, Di Filippo S, Peterson KA, Thiffault I, Bole-Feysot C, Cooley LD, Farrow EG, Masson C, Schoen P, Deleuze JF, Nitschké P, Lyonnet S, de Pontual L, Murray SA, Bonnet D, Kingsmore SF, Amiel J, Bouvagnet P, Lo CW, Gordon CT. Nat Genet. 2015 Nov;47(11):1260-3.
  7. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y, Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J, Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury L, Ganapathiraju MK, Tobita K, Pazour GJ, Lo CW. Nature. 2015 May 28;521(7553):520-4
  8. Respiratory motile cilia dysfunction in a patient with cranioectodermal dysplasia. Li Y, Garrod AS, Madan-Khetarpal S, Sreedher G, McGuire M, Yagi H, Klena NT, Gabriel GC, Khalifa O, Zahid M, Panigrahy A, Weiner DJ, Lo CW. Am J Med Genet A. 2015 Sep;167(9):2188-96.
  9. Wdpcp, a PCP Protein Required for Ciliogenesis, Regulates Directional Cell Migration and Cell Polarity by Direct Modulation of the Actin Cytoskeleton. Cui C, Chatterjee B, Lozito TP, Zhang Z, Francis RJ, Yagi H, Swanhart LM, Sanker S, Francis D, Yu Q, San Agustin JT, Puligilla C, Chatterjee T, Tansey T, Liu X, Kelley MW, Spiliotis ET, Kwiatkowski AV, Tuan R, Pazour GJ, Hukriede NA, Lo CW. PLoS Biol. 2013 Nov;11(11):e1001720.
  10. Yee KK, Yagi H, Matsuoka R, Nakanishi T, Furukawa T. Transrepression activity of T-box1 in a gene regulation network in mouse cells. Gene. 2012 Dec 1;510(2):162-70.
  11. Chida A, Shintani M, Yagi H, Fujiwara M, Kojima Y, Sato H, Imamura S, Yokozawa M, Onodera N, Horigome H, Kobayashi T, Hatai Y, Nakayama T, Fukushima H, Nishiyama M, Doi S, Ono Y, Yasukouchi S, Ichida F, Fujimoto K, Ohtsuki S, Teshima H, Kawano T, Nomura Y, Gu H, Ishiwata T, Furutani Y, Inai K, Saji T, Matsuoka R, Nonoyama S, Nakanishi T. Outcomes of childhood pulmonary arterial hypertension in BMPR2 and ALK1 mutation carriers. Am J Cardiol. 2012 Aug 15;110(4):586-93.
  12. Nakhleh N, Francis R, Giese RA, Tian X, Li Y, Zariwala MA, Yagi H, Khalifa O, Kureshi S, Chatterjee B, Sabol SL, Swisher M, Connelly PS, Daniels MP, Srinivasan A, Kuehl K, Kravitz N, Burns K, Sami I, Omran H, Barmada M, Olivier K, Chawla KK, Leigh M, Jonas R, Knowles M, Leatherbury L, Lo CW. High prevalence of respiratory ciliary dysfunction in congenital heart disease patients with heterotaxy. Circulation. 2012 May 8;125(18):2232-42.
  13. Okubo T, Kawamura A, Takahashi J, Yagi H, Morishima M, Matsuoka R, Takada S. Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice. Development. 2011 Jan; 138(2):339-48.
  14. Ichikawa H, Yagi H, Tanaka T, Cyong JC, Masaki T. Lagerstroemia speciosa extract inhibit TNF-induced activation of nuclear factor-kappaB in rat cardiomyocyte H9c2 cells. J Ethnopharmacol. 2010 Mar 2;128(1):254-6.
  15. Tang S, Hoshida H, Kamisago M, Yagi H, Momma K, Matsuoka R. Phenotypic and genotypic correlation in a patient with co-occurrence of Marfan and LEOPARD syndromes. Am J Med Genet A. 2009 Oct;149A(10):2216-9.
  16. Shintani M, Yagi H, Nakayama T, Saji T, Matsuoka R. A New Nonsense Mutation of SMAD8 Associated with Pulmonary Arterial Hypertension. J Med Genet. May, 2009;46(5):331-7.
  17. Fujiwara M*, Yagi H*, Matsuoka R, Akimoto K, Furutani M, Imamura S, Uehara R, Hoshikawa Y, Nakayama T, Takao A, Nakazawa M, Saji T. (*equally contributed) Implications of mutations of activin receptor-like kinase 1 gene (ALK1) in addition to bone morphogenetic protein receptor II gene (BMPR2) in children with pulmonary arterial hypertension. Circ J. Jan, 2008;72(1):127-133.
  18. Razzaque MA, Nishizawa T, Komoike Y, Yagi H, Furutani M, Amo R, Kamisago M, Momma K, Katayama H, Nakagawa M, Fujiwara Y, Matsushima M, Mizuno K, Tokuyama M, Hirota H, Muneuchi J, Higashinakagawa T, Matsuoka R. Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Nat Genet. Aug, 2007 ;39(8):1013-7.
  19. Yagi H and Matsuoka R. Congenital heart disease and mutations of transcription factors (Tbx, Nkx, and GATA). Molecular Cardiovascular Medicine. Apr 1, 2006; 7(2): 132-7.
  20. Bassuk AG, Craig D, Jalali A, Mukhopadhyay A, Kim F, Charrow J, Gulbu U, Epstein LG, Bowman R, McLone D, Yagi H, Matsuoka R, Stephan DA, Kessler JA. The genetics of tethered cord syndrome.  Am J Med Genet A. Nov 22, 2004; 132A (4):450-453.
  21. Yagi H, Furutani Y, Hamada H, Sasaki T, Asakawa S, Minoshima S, Ichida F, Joo K, Kimura M, Imamura S, Kamatani N, Momma K, Takao A, Nakazawa M, Shimizu N, Matsuoka R. Role of TBX1 in human del22q11.2 syndrome.  Lancet. Oct 25, 2003; 362(9393):1366-73.