• Postdoctoral Associate

Education & Training

  • Postdoctoral Fellow, University of Pittsburgh, 2019
  • PhD, University of Chinese Academy of Sciences, 2015-2019
  • MS, Capital Normal University, 2012-2015

Representative Publications

1. Feng W, Lei T, Wang Y, Feng R, Yuan J, Shen X, Wu Y, Gao J, Ding W, Lu Z. GCN2 deficiency ameliorates cardiac dysfunction in diabetic mice by reducing lipotoxicity and oxidative stress. Free Radic Biol Med. 2019 Jan;130:128-139. PubMed PMID: 30389499.
2. Wang Y, Lei T, Yuan J, Wu Y, Shen X, Gao J, Feng W, Lu Z. GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress. Redox Biol. 2018 Jul;17:25-34. PubMed PMID: 29660505;

Research Interests

My research interest is to uncover the gene expression regulatory mechanisms at the transcriptional and translational level during cardiovascular disease as a means to understand disease pathology. I'm using  state of the art single cell mRNA sequencing approaches to understand the cellular heterogeneity in human heart during development. I will analyze the cardiomyocyte subtype and maturation stages in different differentiation conditions using human iPSCs. The gene expression profile from single cells will precisely map the cell population changes in CHD when compared to normal development. This will reveal the pathogenesis of CHDs and lay a solid foundation to the mechanism of heart defects. To accomplish these goals, I will used newly designed statistical methods to better analyzing the single cell sequencing data acquired with a focus on genes involved in cell-cell signaling and cellular metabolism.